Efficacy & Toxicity
Target Validation
Toxicity Assays
Multi Cancer Screening

INOVOTION has collaborated with multiple research teams, and the publications cited below provide information about INOVOTION's technology. However if you have any questions or comments, feel free to contact us, our scientific team will be delighted to help you.

 

PUBLICATIONS

  • Mauro-Lizcano M, Di Pisa F, Larrea Murillo L, Sugden CJ, Sotgia F, Lisanti MP.
    High mitochondrial DNA content is a key determinant of stemness, proliferation, cell migration, and cancer metastasis in vivo.
    Cell Death Dis. 2024 Oct 11;15(10):745. doi: 10.1038/s41419-024-07103-9. PMID: 39394145; PMCID: PMC11470112.
    Pubmed

 

  • Mercier AE, Joubert AM, Prudent R, Viallet J, Desroches-Castan A, De Koning L, Mabeta P, Helena J, Pepper MS, Lafanechère L.
    Sulfamoylated Estradiol Analogs Targeting the Actin and Microtubule Cytoskeletons Demonstrate Anti-Cancer Properties In Vitro and In Ovo.
    Cancers (Basel). 2024 Aug 23;16(17):2941. doi: 10.3390/cancers16172941. PMID: 39272798; PMCID: PMC11394244.
    Pubmed

 

  • Garcia P, Wang Y, Viallet J, Mehdi NEH, Montaut E, Decaens T, Emadali A, Macek Jílková Z.
    Liver cancer in ovo models for preclinical testing.
    FASEB J. 2024 Sep 15;38(17):e70029. doi: 10.1096/fj.202401416R.
    PMID: 39215630
    Pubmed

 

  • Bakri SJ, Lynch J, Howard-Sparks M, Saint-Juste S, Saim S.
    Vorolanib, sunitinib, and axitinib: A comparative study of vascular endothelial growth factor receptor inhibitors and their anti-angiogenic effects
    PLoS One. 2024 Jun 4;19(6):e0304782. doi: 10.1371/journal.pone.0304782. eCollection 2024.
    PMID: 38833447
    Pubmed

 

  • Daurat M, Gauthier C, El Cheikh K, Ali LMA, Morère E, Bettache N, Gary-Bobo M, Morère A, Garcia M, Maynadier M, Basile I.
    Engineered therapeutic antibodies with mannose 6-phosphate analogues as a tool to degrade extracellular proteins.
    Front Immunol. 2024 Mar 12;15:1273280. doi: 10.3389/fimmu.2024.1273280. eCollection 2024.
    PMID: 38533506
    Pubmed

 

  • Collery P, Prunier C, Dosda E, Viallet J, Harikrishnan A; Veena V, Desmaele D
    Effectiveness of Rhenium(I)-diselenoether Low Doses in a Triple-negative Breast Cancer Chicken Embryo Model
    Anticancer Res. 2024 Mar;44(3):941-951. doi: 10.21873/anticanres.16889.
    PMID: 38423662
    Pubmed

 

  • Dutriaux A, Diazzi S, Bresesti C, Hardouin S, Deshayes F, Collignon J, Flagiello D.
    LADON, a Natural Antisense Transcript of NODAL, Promotes Tumour Progression and Metastasis in Melanoma
    Noncoding RNA. 2023 Nov 15;9(6):71. doi: 10.3390/ncrna9060071.
    PMID: 37987367
    Pubmed

 

  • Barthelemy D, Lescuyer G, Geiguer F, Grolleau E, Gauthier A, Balandier J, Raffin M, Bardel C, Bouyssounouse B, Rodriguez-Lafrasse C, Couraud S, Wozny AS, Payen L.
    Paired Comparison of Routine Molecular Screening of Patient Samples with Advanced Non-Small Cell Lung Cancer in Circulating Cell-Free DNA Using Three Targeted Assays
    Cancers (Basel). 2023 Mar 3;15(5):1574. doi: 10.3390/cancers15051574.
    PMID: 36900363
    Pubmed

 

  • Desette A, Guichet PO, Emambux S, Masliantsev K, Cortes U, Ndiaye B, Milin S, George S, Faigner M, Tisserand J, Gaillard A, Brot S, Wager M, Tougeron D, Karayan-Tapon L.
    Deciphering Brain Metastasis Stem Cell Properties From Colorectal Cancer Highlights Specific Stemness Signature and Shared Molecular Features
    Cell Mol Gastroenterol Hepatol. 2023;16(5):757-782. doi: 10.1016/j.jcmgh.2023.07.008. Epub 2023 Jul 22.
    PMID: 37482243
    Pubmed

 

  • Fischer D, Fluegen G, Garcia P, Ghaffari-Tabrizi-Wizsy N, Gribaldo L, Huang RY, Rasche V, Ribatti D, Rousset X, Pinto MT, Viallet J, Wang Y, Schneider-Stock R.
    The CAM Model – Q&A with Experts
    Cancers (Basel). 2022 Dec 28;15(1):191. doi: 10.3390/cancers15010191. PMID: 36612187
    Pubmed

 

  • Hatat AS, Benoit-Pilven C, Pucciarelli A, de Fraipont F, Lamothe L, Perron P, Rey A, Levra MG, Toffart AC, Auboeuf D, Eymin B, Gazzeri S.
    Altered splicing of ATG16-L1 mediates acquired resistance to tyrosine kinase inhibitors of EGFR by blocking autophagy in non-small cell lung cancer
    Mol Oncol. 2022 Oct;16(19):3490-3508. doi: 10.1002/1878-0261.13229. Epub 2022 Aug 30.
    PMID: 35593080
    Pubmed

 

  • Rousset X, Maillet D, Grolleau E, Barthelemy D, Calattini S, Brevet M, Balandier J, Raffin M, Geiguer F, Garcia J, Decaussin-Petrucci M, Peron J, Benzerdjeb N, Couraud S, Viallet J, Payen L.
    Embryonated Chicken Tumor Xenografts Derived from Circulating Tumor Cells as a Relevant Model to Study Metastatic Dissemination: A Proof of Concept
    Cancers (Basel). 2022 Aug 23;14(17):4085. doi: 10.3390/cancers14174085.
    PMID: 36077622
    Pubmed

 

  • Wang Y, Rousset X, Prunier C, Garcia P, Dosda E, Leplus E, Viallet J.
    PD-1/PD-L1 Checkpoint Inhibitors Are Active in the Chicken Embryo Model and Show Antitumor Efficacy In Ovo.
    Cancers (Basel). 2022 Jun 23;14(13):3095. doi: 10.3390/cancers14133095.
    PMID: 35804865
    Pubmed

 

  • Feliz Morel ÁJ, Hasanovic A, Morin A, Prunier C, Magnone V, Lebrigand K, Aouad A, Cogoluegnes S, Favier J, Pasquier C, Mus-Veteau I. 
    Persistent Properties of a Subpopulation of Cancer Cells Overexpressing the Hedgehog Receptor Patched
    Pharmaceutics. 2022 May 5;14(5):988. doi: 10.3390/pharmaceutics14050988.
    PMID: 35631574
    Pubmed

 

  • Garcia P, Wang Y, Viallet J, Macek Jilkova Z.
    The Chicken Embryo Model: A Novel and Relevant Model for Immune-Based Studies
    Front Immunol. 2021 Nov 19;12:791081. doi: 10.3389/fimmu.2021.791081. eCollection 2021.
    PMID: 34868080
    Pubmed

 

  • Nachtigal MW, Musaphir P, Dhiman S, Altman AD, Schweizer F, Arthur G. 
    Cytotoxic capacity of a novel glycosylated antitumor ether lipid in chemotherapy-resistant high grade serous ovarian cancer in vitro and in vivo
    Transl Oncol. 2021 Nov;14(11):101203. doi: 10.1016/j.tranon.2021.101203. Epub 2021 Aug 17.
    PMID: 34416424
    Pubmed

 

  • Fiorillo M, Ózsvári B, Sotgia F, Lisanti MP.
    High ATP Production Fuels Cancer Drug Resistance and Metastasis: Implications for Mitochondrial ATP Depletion Therapy
    Front Oncol. 2021 Oct 15;11:740720. doi: 10.3389/fonc.2021.740720. eCollection 2021.
    PMID: 34722292
    Pubmed

 

  • Fiorillo M, Scatena C, Naccarato AG, Sotgia F, Lisanti MP.
    Bedaquiline, an FDA-approved drug, inhibits mitochondrial ATP production and metastasis in vivo, by targeting the gamma subunit (ATP5F1C) of the ATP synthase.
    Cell Death Differ. 2021 Sep;28(9):2797-2817. doi: 10.1038/s41418-021-00788-x. Epub 2021 May 13.
    PMID: 33986463
    Pubmed

 

  • Kimani S, Chakraborty S, Irene I, de la Mare J, Edkins A, du Toit A, Loos B, Blanckenberg A, Van Niekerk A, Costa-Lotufo LV, ArulJothi KN, Mapolie S, Prince S.
    The palladacycle, BTC2, exhibits anti-breast cancer and breast cancer stem cell activity
    Biochem Pharmacol. 2021 Aug;190:114598. doi: 10.1016/j.bcp.2021.114598. Epub 2021 May 9.
    PMID: 33979647
    Pubmed

 

  • Sargiacomo C, Stonehouse S, Moftakhar Z, Sotgia F, Lisanti MP.
    MitoTracker Deep Red (MTDR) Is a Metabolic Inhibitor for Targeting Mitochondria and Eradicating Cancer Stem Cells (CSCs), With Anti-Tumor and Anti-Metastatic Activity In Vivo
    Front Oncol. 2021 Jul 30;11:678343. doi: 10.3389/fonc.2021.678343. eCollection 2021.
    PMID: 34395247
    Pubmed

 

  • Byrgazov K, Besse A, Kraus M, Slipicevic A, Lehmann F, Driessen C, Besse L.
    Novel Peptide-drug Conjugate Melflufen Efficiently Eradicates Bortezomib-resistant Multiple Myeloma Cells Including Tumor-initiating Myeloma Progenitor Cells
    Hemasphere. 2021 Jun 12;5(7):e602. doi: 10.1097/HS9.0000000000000602. eCollection 2021 Jul.
    PMID: 34136753
    Pubmed

 

  • Marcion G, Hermetet F, Neiers F, Uyanik B, Dondaine L, Dias AMM, Da Costa L, Moreau M, Bellaye PS, Collin B, Gobbo J, Briand L, Seigneuric R, Kitten O, Cinier M, Garrido C.
    Nanofitins targeting heat shock protein 110: An innovative immunotherapeutic modality in cancer.
    Int J Cancer. 2021 Jun 15;148(12):3019-3031. doi: 10.1002/ijc.33485. Epub 2021 Mar 4.
    PMID: 33506516
    Pubmed

 

  • Ózsvári B, Magalhães LG, Latimer J, Kangasmetsa J, Sotgia F, Lisanti MP.
    A Myristoyl Amide Derivative of Doxycycline Potently Targets Cancer Stem Cells (CSCs) and Prevents Spontaneous Metastasis, Without Retaining Antibiotic Activity.
    Front Oncol. 2020 Sep 15;10:1528. doi: 10.3389/fonc.2020.01528. eCollection 2020.
    PMID: 33042796
    Pubmed

 

  • Byrgazov K, Anderson C, Salzer B, Bozsaky E, Larsson R, Gullbo J, Lehner M, Lehmann F, Slipicevic A, Kager L, Fryknäs M, Taschner-Mandl S.
    Targeting aggressive osteosarcoma with a peptidase-enhanced cytotoxic melphalan flufenamide.
    Ther Adv Med Oncol. 2020 Jul 29;12:1758835920937891. doi: 10.1177/1758835920937891. eCollection 2020.
    PMID: 32774473
    Pubmed

 

  • Leclair HM, Tardif N, Paris A, Galibert MD, Corre S.
    Role of Flavonoids in the Prevention of AhR-Dependent Resistance During Treatment with BRAF Inhibitors.
    Int J Mol Sci. 2020 Jul 16;21(14):5025. doi: 10.3390/ijms21145025.
    PMID: 32708687
    Pubmed

 

  • Achkar IW, Kader S, Dib SS, Junejo K, Al-Bader SB, Hayat S, Bhagwat AM, Rousset X, Wang Y, Viallet J, Suhre K, Halama A.
    Metabolic Signatures of Tumor Responses to Doxorubicin Elucidated by Metabolic Profiling in Ovo
    Metabolites. 2020 Jun 28;10(7):268. doi: 10.3390/metabo10070268.
    PMID: 32605263
    Pubmed

 

  • Signetti L, Elizarov N, Simsir M, Paquet A, Douguet D, Labbal F, Debayle D, Di Giorgio A, Biou V, Girard C, Duca M, Bretillon L, Bertolotto C, Verrier B, Azoulay S, Mus-Veteau I.
    Inhibition of Patched Drug Efflux Increases Vemurafenib Effectiveness against Resistant Braf Melanoma
    Cancers (Basel). 2020 Jun 9;12(6):1500. doi: 10.3390/cancers12061500.
    PMID: 32526884
    Pubmed

 

  • Benedetti R, Dell'Aversana C, De Marchi T, Rotili D, Liu NQ, Novakovic B, Boccella S, Di Maro S, Cosconati S, Baldi A, Niméus E, Schultz J, Höglund U, Maione S, Papulino C, Chianese U, Iovino F, Federico A, Mai A, Stunnenberg HG, Nebbioso A, Altucci L.
    Inhibition of Histone Demethylases LSD1 and UTX Regulates ERα Signaling in Breast Cancer
    Cancers (Basel). 2019 Dec 16;11(12):2027. doi: 10.3390/cancers11122027.
    PMID: 31888209
    Pubmed

 

  • Brun S, Bassissi F, Serdjebi C, Novello M, Tracz J, Autelitano F, Guillemot M, Fabre P, Courcambeck J, Ansaldi C, Raymond E, Halfon P.
    GNS561, a new lysosomotropic small molecule, for the treatment of intrahepatic cholangiocarcinoma.
    Invest New Drugs. 2019 Dec;37(6):1135-1145. doi: 10.1007/s10637-019-00741-3. Epub 2019 Feb 19.
    PMID: 30778887
    Pubmed

 

  • Nascimento BFO, Laranjo M, Pereira NAM, Dias-Ferreira J, Piñeiro M, Botelho MF, Pinho E Melo TMVD.
    Ring-Fused Diphenylchlorins as Potent Photosensitizers for Photodynamic Therapy Applications: In Vitro Tumor Cell Biology and in Vivo Chick Embryo Chorioallantoic Membrane Studies.
    ACS Omega. 2019 Oct 9;4(17):17244-17250. doi: 10.1021/acsomega.9b01865. eCollection 2019 Oct 22.
    PMID: 31656898
    Pubmed

 

  • Alsamri H, El Hasasna H, Al Dhaheri Y, Eid AH, Attoub S, Iratni R.
    Carnosol, a Natural Polyphenol, Inhibits Migration, Metastasis, and Tumor Growth of Breast Cancer via a ROS-Dependent Proteasome Degradation of STAT3.
    Front Oncol. 2019 Aug 8;9:743. doi: 10.3389/fonc.2019.00743. eCollection 2019.
    PMID: 31456939
    Pubmed

 

  • Gilson P, Couvet M, Vanwonterghem L, Henry M, Vollaire J, Baulin V, Werner M, Orlowska A, Josserand V, Mahuteau-Betzer F, Lafanechère L, Coll JL, Busser B, Hurbin A.
    The pyrrolopyrimidine colchicine-binding site agent PP-13 reduces the metastatic dissemination of invasive cancer cells in vitro and in vivo.
    Biochem Pharmacol. 2019 Feb;160:1-13. doi: 10.1016/j.bcp.2018.12.004. Epub 2018 Dec 7.
    PMID: 30529691
    Pubmed

 

  • Arafat K, Al Kubaisy E, Sulaiman S, Karam S, M, Al Natour Z, Hassan A, H, Attoub S.
    SMARCAD1 in Breast Cancer Progression.
    Cell Physiol Biochem. 2018;50(2):489-500. doi: 10.1159/000494163. Epub 2018 Oct 11.
    PMID: 30308496
    Pubmed

 

  • Gilson P, Josa-Prado F, Beauvineau C, Naud-Martin D, Vanwonterghem L, Mahuteau-Betzer F, Moreno A5, Falson P, Lafanechère L, Frachet V, Coll JL, Fernando Díaz J, Hurbin A, and Busser B.
    Identification of pyrrolopyrimidine derivative PP-13 as a novel microtubule-destabilizing agent with promising anticancer properties.
    Sci Rep. 2017 Aug 31;7(1):10209. doi: 10.1038/s41598-017-09491-9.
    PMID: 28860487
    Pubmed

 

  • Al Kubaisy E, Arafat K, De Wever O, Hassan AH, Attoub S.
    SMARCAD1 knockdown uncovers its role in breast cancer cell migration, invasion, and metastasis.
    Expert Opinion on Therapeutic Targets (2016), 20:9, 1035-1043
    Pubmed

 

  • El Hasasna H, Saleh A, Samri HA, Athamneh K, Attoub S, Arafat K, Benhalilou N, Alyan S, Viallet J, Dhaheri YA, Eid A, Iratni R.
    Rhus coriaria suppresses angiogenesis, metastasis and tumor growth of breast cancer through inhibition of STAT3, NFκB and nitric oxide pathways.
    Sci Rep. 2016 Feb 18;6:21144. doi: 10.1038/srep21144.
    PMID: 26888313
    Pubmed

 

  • Kroiss A, Vincent S, Decaussin-Petrucci M, Meugnier E, Viallet J, Ruffion A, Chalmel F, Samarut J, Allioli N.
    Androgen-regulated microRNA-135a decreases prostate cancer cell migration and invasion through downregulating ROCK1 and ROCK2.
    Oncogene. 2015 May 28;34(22):2846-55.
    Pubmed

 

  • Mikaelian I, Malek M, Gadet R, Viallet J, Garcia A, Girard-Gagnepain A, Hesling C, Gillet G, Gonzalo P, Rimokh R, Billaud M.
    Genetic and pharmacologic inhibition of mTORC1 promotes EMT by a TGF-β-independent mechanism.
    Cancer Res. 2013 Nov 15;73(22):6621-31.
    Pubmed

 

  • Al Dhaheri Y, Attoub S, Arafat K, Abuqamar S, Viallet J, Saleh A, Al Agha H, Eid A, Iratni R.
    Anti-metastatic and anti-tumor growth effects of Origanum majorana on highly metastatic human breast cancer cells: inhibition of NFκB signaling and reduction of nitric oxide production.
    PLoS One. 2013 Jul 10;8(7):e68808.
    Pubmed

 

  • Prudent R, Vassal-Stermann É, Nguyen CH, Mollaret M, Viallet J, Desroches-Castan A, Martinez A, Barette C, Pillet C, Valdameri G, Soleilhac E, Di Pietro A, Feige JJ, Billaud M, Florent JC, Lafanechère L.
    Azaindole derivatives are inhibitors of microtubule dynamics, with anticancer and anti-angiogenic activities.
    Br J Pharmacol. 2013 Feb;168(3):673-85.
    Pubmed

 

PATENTS

 

  • Kotora et al.
    15p-substituted estrone derivatives as selective inhibitors of 17p-hydroxysteoid-dehydrogenases, method of preparation and use thereof.
    WO2017/211330. December 14, 2017

 

  • Guedat and Miniou.
    Method of treating cancer with a combination of benzylideneguanidine derivatives and chemotherapeutic agent.
    WO2017/021216 A1. February 9, 2017

 

  • Lafanechère et al.
    5-Azaindole compounds with anticancer and antiangiogenic activities.
    WO2014/033597 A1. March 6, 2014.