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The Chicken Embryo Model: a Relevant In Vivo Model for Biomaterial Characterization
| Authors: | Chloé Prunier, Xavier Rousset, Yan Wang, Emilien Dosda and Jean Viallet |
| Abstract: | In vivo characterization of biomaterials is essential for regulatory approval. However, preclinical rodent models face ethical concerns, prompting increasing support for the 3Rs — reduction, refinement, and replacement. The chicken embryo model offers an alternative to animal experimentation for a large number of applications including drug development and biocompatibility assessment. Both FDA and ECVAM have recognized the added value of the model for toxicity and chronic wound healing applications, with demonstrated predictivity for rodent responses. At Inovotion, we use the chicken embryo model, more specifically the ChorioAllantoic Membrane (CAM), to implant and evaluate biomaterials' biocompatibility. This platform enables comprehensive assessment of toxicity, pharmacokinetic, tissue integration and angiogenic potential. The CAM model provides valuable preclinical data for a diverse set of applications, including tissue engineering, regenerative medicine, drug delivery, and wound healing, facilitating biomaterials' development while maintaining ethical standards. |
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